Product ID:L-LEUCINE, L8000
MSDS Date:07/01/1999
FSC:6505
NIIN:00N092457
Status Code:A
MSDS Number: CJVSV

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

L-LEUCINE

CAS: 61-90-5

RTECS: OH2850000

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFO
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: MAY BE HARMFUL BY
INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION.
MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS
MEMBRANES AND UPPER RESPIRATORY TRA CT. TO THE BEST OF
MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL
PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ADDITIONAL
INFORMATION: THE LEVOROTARY (L) FORM OF LEUCINE, ISOL EUCINE AND
VALINE HAVE BEEN FOUND TO HAVE TUMOR-PROMOTING ACTIVITY FOR BLADDER
CARCINOMAS. SCIENCE 231, 843, 21 FEBRUARY 1986. ALSO, SEE
TOXICOLOGICAL INFORMATION.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IN CASE OF CONTACT,
IMMEDIATELY FLUSH SKIN WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST
15 M INUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES.
INHALATION: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIOUS. CALL A PHYSICIAN. DISCARD CONTAMINATED CLOTHING AND
SHOES.

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT TO PREVENT CONTACT WITH SKIN AND EYES.
Unusual Fire/Explosion Hazard:THIS MATERIAL, LIKE MOST MATERIALS IN
POWDER FORM, IS CAPABLE OF CREATING A DUST EXPLOSION. EMITS TOXIC
FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED
MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND
REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP
IS COMPLETE.

Handling and Storage Precautions:KEEP TIGHTLY CLOSED. STORE IN A COOL,
DRY PLACE.
Other Precautions:AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN AND
CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. WASH THOROUGHLY
AFTER HANDLING.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health

Melt/Freeze Pt:>300.C, 572.F
Appearance and Odor:WHITE POWDER.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
CARBON DIOXIDE. NITROGEN OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULAITONS.

Toxicological Information:RTECS #: OH2850000 LEUCINE, L-. TOXICITY
DATA: IPR-RAT LD50: 5379 MG/KG ABBIA4 58,253,1955. TARGET ORGAN
DATA: EFFECTS OF FERTILITY (POST-IMPLANTATION MORTALITY). EFFECTS
ON EMBRYO OR FETUS (FETOTOXIC ITY). SPECIFIC DEVELOPMENTAL
ABNORMALITIES (CENTRAL NERVOUS SYSTEM). SPECIFIC DEVELOPMENTAL
ABNORMALITIES (EYE, EAR). SPECIFIC DEVELOPMENTAL ABNORMALITIES
(CRANIOFACIAL). SPECIFIC DEVELOPMENTAL ABNORM ALITIES (BODY WALL).
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM).
SPECIFIC DEVELOPMENTAL ABNORMALITIES (UROGENITAL SYSTEM). SPECIFIC
DEVELOPMENTAL ABNORMALITIES (OTHER INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS:
OEL=MAK. OEL-RUSSIA: STEL 5 MG/M3 JAN 1993. NOHS 1974: HZD 81818;
NIS 1; TNF 53; NOS 3; TNE 750. NOES 1983: HZD 81818; NIS 4; TNF
1037; NOS 18; TNE 21979; TFE 1615 3. EPA TSCA SECTION 8(B) CHEMICAL
INVENTORY.